|
Symbol Name ID |
Shh
sonic hedgehog MGI:98297 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Aganglionic megacolon |
Intestinal atresia |
Intestinal obstruction |
Intestinal polyposis |
Constipation |
Diarrhea |
Nausea and vomiting |
Functional abnormality of the gastrointestinal tract |
Gastroesophageal reflux |
| Disease(s) Associated with SHH | |||||||||
| Hirschsprung's disease | |||||||||
| holoprosencephaly |
| Mouse Phenotypes | abnormal maxillary shelf morphology |
decreased maxillary shelf size |
absent palatine bone horizontal plate |
abnormal palatal shelf fusion at midline |
palatal shelves fail to meet at midline |
persistence of medial edge epithelium during palatal shelf fusion |
palatal shelf hypoplasia |
abnormal palatal rugae morphology |
decreased palatal rugae number |
cleft secondary palate |
cleft palate |
digestive/alimentary phenotype |
abnormal digestive system morphology |
anal atresia |
abnormal digestive organ placement |
abnormal foregut morphology |
abnormal esophagus morphology |
tracheoesophageal fistula |
abnormal colon morphology |
abnormal small intestine morphology |
abnormal duodenum morphology |
abnormal submandibular gland morphology |
abnormal gastric surface mucous cell morphology |
abnormal stomach glandular epithelium morphology |
stomach epithelial hyperplasia |
gastric metaplasia |
small stomach |
abnormal stomach pH |
aerophagia |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||
| Shhtm1Amc/Shhtm1Amc | ||||||||||||||||||||||||||||||
| Shhtm1Chg/Shhtm1Chg | ||||||||||||||||||||||||||||||
| Shhtm3(cre)Chg/Shhtm3(cre)Chg | ||||||||||||||||||||||||||||||
| Tg(KRT14-Shh)#Cobm/0 | ||||||||||||||||||||||||||||||
| Shhtm2Amc/Shhtm2Amc Tg(Atp4b-cre/ERT2)1Jrgo/0 (conditional) |
* | |||||||||||||||||||||||||||||
| Shhtm2Chg/Shh+ Edil3Tg(Sox2-cre)1Amc/Edil3+ (conditional) |
||||||||||||||||||||||||||||||
| Shhtm1Amc/Shhtm2Amc Tg(KRT14-cre)1Amc/0 (conditional) |
||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/30/2024 MGI 6.23 |
|
|
|
||
Analysis Tools